LY 156735
LY 156735
CAS: 118702-11-7
Molecular Formula: C14H17ClN2O2
LY 156735 - Names and Identifiers
| Name | LY 156735 |
| Synonyms | PD-6735 TIK-301 LY 156735 |
| CAS | 118702-11-7 |
LY 156735 - Physico-chemical Properties
| Molecular Formula | C14H17ClN2O2 |
| Molar Mass | 280.75 |
| In vivo study | In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake. The T max and half-life of TIK-301 is 1.1 hour and 1 hour, respectively. |
LY 156735 - References
| biological activity | TIK-301 (PD-6735) is a chlorinated melatonin derivative that is a potent, high affinity and orally active melatonin MT1 and MT2 receptor agonists with Ki of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 can be used for the study of sleep disorders and other circadian rhythm disorders. |
Last Update：2024-04-09 21:04:16
